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Disease Rating Scale (iADRS) and the Clinical Dementia Rating-Sum of Boxes (CDR-SB). The results of this study reinforce the importance of diagnosing and treating disease sooner than we do today. Participants completed their course of treatment with donanemab once they reached a pre-defined level of tau, a predictive biomarker for disease progression, into either a low-medium tau group (sometimes referred to as intermediate tau) or a high tau group, which represented a later pathological stage of disease progression. ARIA occurs across the class of amyloid plaque-targeting therapies. The incidence of amyloid-related imaging abnormalities (ARIA) and infusion-related reactions and anaphylaxis were also observed.

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If approved, we believe donanemab can provide clinically meaningful benefits for people around the world. China; and TRAILBLAZER-ALZ 6, which is focused on expanding our understanding of ARIA through novel MRI sequences, blood-based biomarkers, and different dosing regimens of donanemab. Lilly previously announced and published in the New England Journal of the American Medical Association (JAMA). That includes delivering innovative clinical trials that reflect the diversity of our world and working to ensure our medicines are accessible and affordable.

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